Suitable for use in ELISA, Western Blot, Immunohistochemistry ａnd quantification of myelin basic protein. Other applications have not been tested. Recognizes residues 130-136 in human myelin basic protein (21.5kD ａnd 18.5kD molecular forms). Species Crossreactivity: Primate, rabbit, sheep, goat, rat ａnd mouse. The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation ａnd stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) found in bone marrow ａnd the immune system may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, ａnd may also be involved in signaling pathways in T-cells ａnd neural cells.
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Myelin Basic Protein monoclonal antibody was raised against amino acids 130 - 136 of Myelin Basic Protein (Human).

ELISAIHCWB

GoatHumanMousePrimateRabbitRatSheep