PPP1CA is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, ａnd HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human ａnd mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning ａnd memory.The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, ａnd HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human ａnd mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning ａnd memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.1) Lesage, B., (2007) Biochemistry 46 (31), 8909-8919.
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Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PPP1CA.

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