BRCA1, which functions as a tumor suppressor in human breast cancer cells, is a nuclear phosphoprotein which associates with RNA polymerase II holoenzyme. Mutations in BRCA1 are predicted to be responsible for approximately 45% of inherited breast cancer ａnd more than 80% of inherited breast ａnd ovarian cancer. BRCA1 may function as a transcriptional regulator, due to an amino terminal DNA-binding ring finger motif, nuclear localization signals, ａnd an acidic carboxy terminal domain. BRCA1 is also a granin-like protein that functions as a secreted growth inhibitory protein. BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth. This function is compromised in breast cancer either by direct mutation or by alterations in gene expression.1) Mark, W.Y., et al., (2005) J. Mol. Biol. 345 (2), 275-287.
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Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human BRCA1.

ELISAIHCWB

Human