Introduction:

Marijuana, one of the most widely abused drugs, after
alcohol, is derived from the Cannabis Sativa plant. There
are more than 400 chemicals in the cannabis plant. The
Δ9-tetrahydrocannabinol (THC) is the most psychoactive of
the various forms of THC. Marijuana is most often used in
cigarette form, the user inhaling the marijuana smoke. THC
and other forms of cannabinoids are lipid soluble and can enter
into body tissues rapidly. THC is rapidly metabolized to 11-
hydroxy-Δ9-tetrahydocannabinol (11-OH-THC), which is then
converted into 11-nor-Δ9-THC-9-carboxylic acid (THC-COOH).
Detection of THC metabolites in urine, primarily THC-COOH,
impairment. Testing for THC and its metabolites in blood can
give a better indication of recent drug usage and can be of
merit when testing for impairment. This application note shows an effective SPE method for the
extraction of THC and key metabolites from human blood and
the GC/MS analysis of these compounds.

原創(chuàng)作者：泉島公司--色譜消耗品專家